IGF-1 LR3 1mg

IGF-1 LR3 (Insulin-like Growth Factor-1 Long Arg3) is a synthetic, 83-amino acid analogue of human IGF-1, engineered for extended biological half-life and enhanced receptor-binding affinity in controlled laboratory environments. Available at Revo Peptide at ≥98% purity, this compound is supplied as a lyophilized white powder in a sealed research vial. For research use only. Not for human or veterinary use. Not for clinical, diagnostic, or consumptive applications.

Product Overview

IGF-1 LR3 is a structurally modified variant of endogenous IGF-1, distinguished by an N-terminal 13-amino acid extension and a glutamic acid-to-arginine substitution at position 3. These modifications significantly reduce binding affinity to IGF-binding proteins (IGFBPs), resulting in a prolonged circulating half-life compared to the native peptide. Widely referenced in peer-reviewed in vitro and ex vivo research, IGF-1 LR3 is a cornerstone compound for investigators studying growth factor signalling, cellular proliferation pathways, and metabolic regulation at the molecular level. Revo Peptide offers this compound for sale to qualified research institutions and licensed laboratory professionals.

Peptide Structure & Amino Acid Sequence

IGF-1 LR3 is an 83-residue polypeptide with the following full amino acid sequence:

H-Met-Phe-Pro-Ala-Met-Pro-Leu-Ser-Ser-Leu-Phe-Val-Asn-Gly-Pro-Arg-Thr-Leu-Cys-Gly-Ala-Glu-Leu-Val-Asp-Ala-Leu-Gln-Phe-Val-Cys-Gly-Asp-Arg-Gly-Phe-Tyr-Phe-Asn-Lys-Pro-Thr-Gly-Tyr-Gly-Ser-Ser-Ser-Arg-Arg-Ala-Pro-Gln-Thr-Gly-Ile-Val-Asp-Glu-Cys-Cys-Phe-Arg-Ser-Cys-Asp-Leu-Arg-Arg-Leu-Glu-Met-Tyr-Cys-Ala-Pro-Leu-Lys-Pro-Ala-Lys-Ser-Ala-OH

The peptide contains three intramolecular disulfide bridges critical to its tertiary structure and receptor-binding competency. The N-terminal extension (Met-Phe-Pro-Ala-Met-Pro-Leu-Ser-Ser-Leu-Phe-Val-Asn) is the key structural feature that differentiates LR3 from native IGF-1 and underpins its reduced IGFBP affinity in research models.

Chemical & Physical Characteristics

• Appearance: White to off-white lyophilized powder
• Molecular Formula: C₄₀₀H₆₂₅N₁₁₁O₁₁₅S₉
• Molecular Weight: Approximately 9,117 Da
• Solubility: Soluble in sterile water or aqueous buffer solutions
• Storage Temperature: −20°C (long-term); 4°C (short-term, up to 4 weeks)
• CAS Number: 946870-92-4

Purity & Analytical Verification (HPLC & MS)

Every batch of IGF-1 LR3 supplied by Revo Peptide is manufactured to a minimum purity of ≥98%, with select lots achieving >99% purity as confirmed by reverse-phase high-performance liquid chromatography (RP-HPLC). Mass spectrometry (MS) analysis is performed on each production lot to confirm correct molecular weight and sequence integrity. These analytical procedures ensure that researchers receive a compound of consistent, reproducible quality suitable for demanding in vitro experimental protocols.

Quality Control & Lyophilization Integrity

IGF-1 LR3 is lyophilized under controlled vacuum conditions to remove residual moisture and extend shelf stability without compromising peptide structure. Each vial undergoes rigorous quality control checks, including visual inspection for cake integrity, residual moisture testing, and endotoxin screening where applicable. Lot-specific certificates of analysis (CoA) are available upon request, providing full traceability from synthesis through final QC release. Revo Peptide’s commitment to quality control ensures that every order meets the exacting standards demanded by serious research applications.

Safety, Handling & Laboratory Precautions

IGF-1 LR3 is intended exclusively for use by trained laboratory professionals operating within appropriately equipped research facilities. Standard laboratory personal protective equipment (PPE) — including nitrile gloves, safety glasses, and a laboratory coat — should be worn during all handling procedures. This compound should be treated as a potentially biologically active research material; avoid inhalation of lyophilized powder and prevent contact with skin or mucous membranes. All waste materials must be disposed of in accordance with applicable institutional biosafety guidelines and local regulatory requirements.

Reconstitution, Packaging & Storage

For in vitro research applications, IGF-1 LR3 lyophilized powder may be reconstituted using sterile, endotoxin-free water or an appropriate aqueous buffer as determined by the principal investigator’s experimental design. Reconstituted solutions should be aliquoted into single-use volumes to minimize freeze-thaw cycling, which can degrade peptide integrity over time. Store the lyophilized vial at −20°C in a dry, dark environment away from direct light and humidity. Once reconstituted, solutions should be used promptly or stored at 4°C for short-term use only. Packaging is designed to maintain cold-chain integrity during transit.

Intended Research Use & Market Positioning

IGF-1 LR3 is a highly cited research tool in the fields of molecular biology, endocrinology, and cell biology. Its utility in studying IGF receptor activation, PI3K/Akt/mTOR signalling cascades, and anabolic cellular pathways makes it a valuable compound for academic and pharmaceutical research laboratories. Revo Peptide positions IGF-1 LR3 as a premium-grade, competitively priced research peptide for sale to qualified buyers seeking reliable, reproducible results. This product is not intended to serve any therapeutic, diagnostic, or consumptive purpose.

Ordering, Availability & Fulfillment

IGF-1 LR3 is available to order online through Revo Peptide with fast dispatch and secure packaging. Bulk purchase discounts are available for laboratories requiring larger quantities, providing excellent value at the best price without compromising on quality or analytical traceability. Orders are processed promptly, and all shipments are packaged with appropriate cold-chain materials to preserve peptide integrity during transit. Contact our team for volume pricing, custom lot requests, or certificate of analysis inquiries.

Legal & Regulatory Disclaimer

For research use only. Not for human or veterinary use. Not for clinical, diagnostic, or consumptive applications. IGF-1 LR3 is sold exclusively as a laboratory research reagent. Purchasers are solely responsible for ensuring that acquisition, possession, and use of this compound complies with all applicable federal, state, and local laws and regulations in their jurisdiction. Revo Peptide makes no representations regarding the safety, efficacy, or suitability of this compound for any application beyond controlled in vitro laboratory research. By placing an order, the buyer confirms that they are a qualified research professional and that the compound will be used solely for lawful scientific research purposes.